Matthew Perry, the American actor best known for playing Chandler Bing on the hit television sitcom Friends, died from the acute effects of ketamine, according to findings released by the Los Angeles County Department of Medical Examiner in December 2023. He was 54.
The medical examiner ruled Perry’s death an accident. The official report also identified drowning, coronary artery disease and the effects of buprenorphine, a medication used to treat opioid use disorder, as contributing factors. <Cite refs={
What Caused Matthew Perry’s Death?
Perry was found unresponsive in the swimming pool at his Pacific Palisades home in Los Angeles on October 28, 2023. Emergency responders pronounced him dead at the scene.
The subsequent autopsy found ketamine levels in his blood consistent with those used during general anesthesia. According to the medical examiner, the drug’s acute effects caused cardiovascular overstimulation and respiratory depression, impairing Perry’s ability to remain safe in the water. <Cite refs={[“turn386790search1″,”turn386790search4”]}/>
Perry had reportedly been receiving ketamine infusion therapy for depression and anxiety. However, investigators concluded that his most recent reported treatment, approximately a week and a half before his death, could not explain the levels found in his blood. The precise route by which the ketamine entered his system was listed as unknown. <Cite refs={[“turn386790search4″,”turn386790search9”]}/>
A Career That Reached Millions
Perry became internationally recognised through Friends, which ran for 10 seasons between 1994 and 2004. His portrayal of Chandler Bing, known for his quick wit and distinctive humour, made him one of the sitcom’s most recognisable stars.
Away from television, Perry spoke publicly about his long struggle with addiction. His 2022 memoir, Friends, Lovers, and the Big Terrible Thing, described his experiences with substance use and his efforts to achieve sobriety. <Cite refs={
Remembering Matthew Perry
Perry’s death renewed public discussion about addiction, treatment and the risks associated with sedating medications. His story also highlighted the importance of medical supervision and careful monitoring when powerful drugs are used therapeutically.
The official finding remains that Perry died from the acute effects of ketamine, with other medical factors contributing to his death. His performances continue to reach audiences through reruns and streaming services.